On the Reversible Enzyme Inhibition by Tetraethyl Pyrophosphate (TEPP).
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چکیده
منابع مشابه
The reversible inhibition of acetylesterase by diisopropyl fluorophosphate and tetraethyl pyrophosphate.
Diisopropyl fluorophosphate (DFP) has been shown to be a remarkably potent inhibitor of the enzymatic hydrolysis of acetylcholine (1). As a result of a wide survey (2), inhibition by dialkyl fluorophosphates appears to be specific for certain esterases and lipases (kidney acid phosphatase was found to be inhibited by relatively high concentrations). Since the cholinesterase of mammalian brain a...
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When 7 X 10~M tetraethylpyrophosphate (TEPP) was administered as constant perfusion, the results were: (1) A progressive slowing of atrial rate and subsequent block in conduction; (2) A decrease in slope of the prepotential of pacemaker fibers; (3) No significant change in membrane resting potential of sinoatrial and atrial fibers, even during block in conduction; (4) An accelerated repolarizat...
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In this study the role of CA1 region of dorsal hippocamus an amygdala kindling rate was investigated by bilateral microinjection of lidocaine into hippocampus.28 rats were divided into four groups.in group I:animals were implanted only with a tripolar electrode into the amygdala but in groups 2-4,two guide cannulaae were also implanted into the CA1 region of the dorsale hippocampus.two monopol...
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The growth of a thiamine pyrophosphate auxotroph of Escherichi coli was inhibited by either thiamine or thiamine monophosphate, and the growth of a thiamine monophosphate auxotroph was inhibited by thiamine. The thiamine pyrophosphate-dependent oxidation of pyruvate was inhibited by thiamine with whole cells of the thiamine pyrophosphate auxotroph but not with cell extracts prepared from the sa...
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ies within the twenty-five square degrees area are fainter than that magnitude. (c) The distribution over the plates has been used to examine the nature of the various systematic errors of discovery and measurement. An error arising from plate tilt is intimated; but there is very little suggestion of error from neglected distance correction (figures 1 and 2). (d) The belt at +43?6 crosses the M...
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ژورنال
عنوان ژورنال: Acta Chemica Scandinavica
سال: 1952
ISSN: 0904-213X
DOI: 10.3891/acta.chem.scand.06-1477